aeruginosa infection are known to have a lower quality of life than those with other bacterial infections, and are at risk of an accelerated decline in lung function and more frequent exacerbations or flares. The bacteria has a tendency to persist in bronchiectatic airways, due to its ability to produce virulence factors and modulate immune defences by quorum signaling and biofilm production. Found in moist locations, such as soil and water, it is an opportunistic pathogen, taking advantage of weakened immune defenses and, in people bronchiectasis or cystic fibrosis, excessive mucus accumulation and poor lung function. aeruginosa is a gram-negative bacteria, meaning that it is resistant to many medicines and increasingly resistant to available antibiotics. About one-third of bronchiectasis patients are known to have chronic P. Chronic cough, airway obstruction, and infections that come and go and cause damage to the bronchi and bronchioles are characteristic of bronchiectasis, leaving people with this disease susceptible to serious infections with bacterial pathogens and fungal microbes.Īmong the most common bacterial pathogens isolated in bronchiectasis are Haemophilus influenzae, a bacteria that can cause problems ranging from ear infections and bronchitis to pneumonia, and Pseudomonas aeruginosa, which can cause of variety of respiratory infections, including pneumonia, and severe systemic infections.